Compared with the expression levels in the ox-LDL group, the expression of ALP, BMP-2, and Runx2 in VSMC-derived foam cells was upregulated by CML and ox-LDL costimulation by 1.22-fold (0.7187±0.023 vs. 0.587±0.016), 1.62-fold (0.5193±0.013 vs. 0.319±0.008), and 1.53-fold (0.5145±0.0202 vs. 0.3373±0.0149), respectively (Figures 5E–G). Here, RUNX2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.