AKT1 and rheumatoid arthritis: Moreover, the phosphorylation levels of the Akt/mTOR signaling pathway and its downstream molecules, p70 ribosomal S6 kinase (p70S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), in RA-FLSs were evaluated with Western blot to explore the effect of Tan IIA on the mTOR pathway.