Meanwhile, the increased phosphorylation of p70S6K and 4E-BP1 triggered by TNF-α was also inhibited by Tan IIA treatment in a concentration-dependent manner, suggesting that Tan IIA suppressed the Akt/mTOR/p70S6K and 4E-BP1 signaling pathway in RA-FLSs. The gene discussed is AKT1; the disease is rheumatoid arthritis.