TNF-α is one of the most important inflammatory cytokines in the joint cavity of RA patients and is commonly used as an activator of RA-FLSs in vitro to simulate the inflammatory microenvironment (Shi et al., 2018; Du et al., 2019; Wang Z. et al., 2019; Wu et al., 2019). The gene discussed is TNF; the disease is rheumatoid arthritis.