To discover the effect of Tan IIA on the viability of RA-FLSs induced by TNF-α, the effect of Tan IIA with a series of concentrations (0, 2.5, 5, 10, and 20 μM) on the viability of RA-FLSs activated with TNF-α was measured. The gene discussed is TNF; the disease is rheumatoid arthritis.