HIF1A and cancer: It is of note that the data show that the potential target genes found were functionally related with various signal transduction pathways, including the PI3K-Akt signaling pathway, proteoglycans in cancer, pancreatic cancer; Kaposi sarcoma-associated herpesvirus infection, human cytomegalovirus infection, the MAPK signaling pathway, choline metabolism in cancer, and the hypoxia-inducible factor (HIF-1) signaling pathway (Figure 5C).