TNF and early-onset autosomal dominant Alzheimer disease: Beyond the diseases that imply greater socioeconomic impact, Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder in the world characterized by the accumulation of β-amyloid (Aβ) protein in the brain parenchyma, the formation of neurofibrillary tangles, glial activation and production of inflammatory mediators such as NO, interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α; Zotova et al., 2013; Alasmari et al., 2018).