Several autosomal dominant missense mutations in LRRK2 are causal for PD and aberrant LRRK2 activity can influence both lysosomal dysfunction and αSyn dyshomeostasis (Henry et al., 2015; Hockey et al., 2015; Bae et al., 2018; Novello et al., 2018; Schapansky et al., 2018). Here, LRRK2 is linked to Parkinson disease.