SMAD6 and congenital rubella syndrome: Combining these unbiased findings with eight additionalindependently identified (see Supplementary Information) SMAD6-positive CRS patients (three MS, three SS, onesagittal + bicoronal and one unicoronal synostosis; Fig. S2), in total we identified 25 differentdamaging variants in SMAD6 (Fig. 1, Table S2) in 28 affected individuals from 26 unrelated familieswith CRS.