SMAD6 and congenital rubella syndrome: Overall, we believe that the data presented here support adoption ofSMAD6 genetic testing to inform geneticdiagnosis of CRS: in the 13-year Oxford birth cohort study,2 10 of 677 (1.5%) individualsharbor rare, damaging SMAD6 variants, makingSMAD6 the fifth most common gene for whichvariants are found in CRS within this cohort.