Furthermore we note that the rs1884302 SNP wasoriginally investigated because it showed the strongest relationship withnonsyndromic SS in a GWAS,19 but more recent data for MS reveal noequivalent association for this SNP.37 Given that the majority of individuals withdeleterious SMAD6 variants have MS, it is perhapsunsurprising that we did not find an overall interaction between SMAD6 variants and rs1884302 genotype. This evidence concerns the gene SMAD6 and synovial sarcoma.