We findthat MS is most highly represented; 5.8% of patients with this diagnosis (Fig.2a) had a rare, damaging SMAD6 variant, by far the largest monogeniccontribution to MS yet identified.2SMAD6 variants were less commonly associated withother types of suture fusion, in particular variants were significantly lessfrequent in SS (0.95% of cases overall) than in MS. The gene discussed is SMAD6; the disease is myeloid sarcoma.