Moreover, CRIPSR-Cas 9 depletion of Gas6 in B16 cells reduced the enhanced tumour growth in pdgfrβcre+;fakfl/fl mice, but had no significant effect in pdgfrβcre-;fakfl/fl mice, indicating that tumour cell derived Gas6 is involved in the enhanced tumour responses in pdgfrβcre+;fakfl/fl mice (Fig. 3b). The gene discussed is GAS6; the disease is neoplasm.