In vivo, the loss of Gas6 in FAKKO pericytes also reduced tumour size and angiogenesis in mice co-injected with FAK-null;Gas6KO and B16F0 tumour cells compared with mice co-injected with FAK-null;Cas9 pericytes and B16 tumour cells (Fig. 3h). This evidence concerns the gene PTK2 and neoplasm.