AKT1 and neoplasm: We recently demonstrated that DARPP-32 and t-DARPP promote non-small cell lung cancer (NSCLC) growth in orthotopic mouse models, reduce apoptosis, activate Akt and Erk signalling, and enhance IKKα-mediated lung tumour cell migration.8 Immunostaining of 62 human lung adenocarcinoma tissues showed that t-DARPP expression is elevated with increasing tumour staging score, a metric of tumour progression and growth.