Numerous studies have reported the oncogenic role of DARPP-32 isoforms in breast and gastric malignancies.29,46 Recently, we demonstrated that overexpression of DARPP-32 isoforms in NSCLC promotes tumour growth.8 Based on these findings, we sought to investigate whether DARPP-32 isoforms contribute to the oncogenesis of SCLC. The gene discussed is PPP1R1B; the disease is small cell lung carcinoma.