The vast majority of cancer studies demonstrate that DARPP-32 and t-DARPP share similar oncogenic functions,29 which corresponds to our in vitro functional data (Figs. 1 and 2) and orthotopic mouse model results (Fig. 3), suggesting that DARPP-32 and t-DARPP overexpression promotes SCLC growth. This evidence concerns the gene PPP1R1B and cancer.