Furthermore, BET inhibitors reportedly suppress the expression of genes involved in immune checkpoints, and the combination of a PD-1 monoclonal antibody drug and JQ1 was effective in Eμ-Myc lymphoma mice.63,64 Since immunotherapy is performed in the treatment of head and neck cancer, the combination with a BET inhibitor may have further beneficial effects. This evidence concerns the gene DNER and head and neck cancer.