In agreement with this, the BRD4 expression level correlated with the prognoses in head and neck cancer, ovarian cancer, and urothelial carcinoma of the bladder.21,59,60 BRD4 may regulate various genes, including those reported as biomarkers, such as HIF1A, VIM, MALAT1, TP53, and NOTCH1. Our ChIP-seq analysis of HOC313 cells confirmed the enrichment of H3K27ac at these loci (data not shown). The gene discussed is HIF1A; the disease is bladder transitional cell carcinoma.