AGO2 and familial pancreatic carcinoma: Importantly, extending the IF analysis to human pancreatic tissues, we observed a similar pattern of localization of RAS and AGO2 with increased RAS-AGO2 co-staining signals at the plasma membrane associated with pancreatic cancer progression (PCC, normal to PDAC increased from 0.1 to 0.5, respectively) (Fig. 5f).