Surprisingly, mice aged over 400 days showed significantly increased pancreatic weights in both the AGO2+/+;KRASG12D;p48Cre and AGO2fl/+;KRASG12D;p48Cre cohort compared with AGO2fl/fl;KRASG12D;p48Cre mice, suggestive of a higher tumor burden in mice with at least one functional allele of AGO2 (Fig. 1d). Here, AGO2 is linked to neoplasm.