AGO2 and familial pancreatic carcinoma: Since precancerous lesions have been shown to undergo oncogene-induced senescence (OIS) in the pancreatic cancer mouse model20, we performed OIS-associated β-galactosidase staining in pancreatic tissue sections of AGO2+/+;KRASG12D;p48Cre and AGO2fl/fl;KRASG12D;p48Cre mice.