GLI3 and Hepatic fibrosis: For instance, miR-378a-3p was demonstrated to limit activation of HSCs and liver fibrosis by targeting Gli3 expression.14 Conversely, miR-214 promotes HSC activation and liver fibrosis by suppressing Sufu expression.15 In addition, multiple miRNAs (i.e. miR-122, miR-101, miR-133a, miR-221/222, miR-181b and miR-19b) participate in controlling HSC activation and liver fibrosis.16–21