The involvement of GOT2 in cancer cell metabolism is mainly reflected in the following three aspects: (1) GOT2 catalyzes the formation of glutamic acid and oxaloacetate from aspartic acid and α-glutaric acid, which participate in the Krebs cycle and may provide energy for tumor cells; (2) GOT2 is a key enzyme in the transfer of malate-aspartate in glycolysis and participates in the amino acid metabolism of tumor cells [55, 56]. Here, GOT2 is linked to neoplasm.