The majority of up-regulated genes are known hematopoietic genes such as Ptprc (CD45), Dock2 (Oatley et al. 2020), Spn (CD43), Myb, and Neurl3, which was recently shown to selectively mark HSC-primed HE (Fig. 2D; Hou et al. 2020). The gene discussed is SPN; the disease is hereditary elliptocytosis.