The importance of the DEDD family deadenylases is underscored by genetic mutations in PARN and TOE1 genes leading to specific subtypes of human disorders dyskeratosis congenita and pontocerebellar hypoplasia (PCH), respectively (Dhanraj et al. 2015; Stuart et al. 2015; Tummala et al. 2015; Lardelli et al. 2017). Here, PARN is linked to pontocerebellar hypoplasia.