The importance of the DEDD family deadenylases is underscored by genetic mutations in PARN and TOE1 genes leading to specific subtypes of human disorders dyskeratosis congenita and pontocerebellar hypoplasia (PCH), respectively (Dhanraj et al. 2015; Stuart et al. 2015; Tummala et al. 2015; Lardelli et al. 2017). This evidence concerns the gene TOE1 and pontocerebellar hypoplasia.