This subgroup also had more severe depressive symptoms.94 Furthermore, there is evidence that symptom clusters of depression may contribute to the ‘inflamed’ subtype; for example anhedonia has been associated with increased CRP and atypical depressive symptoms (increased appetite, weight gain) have been associated with increased CRP, IL-1RA and IL-6.95,96. The gene discussed is IL6R; the disease is depressive disorder.