Similar to the patient’s symptoms, the lung was most obviously the organ majorly affected by SARS-CoV infection in K18-hACE2 Tg mice, showing significant inflammatory reactions (IFN-gamma, CXCL-1, CXCL-10, IL-6, IL-1beta, etc.)hemorrhage, epithelial cell damage, and congestion of alveolar septum (Fig. 2) [66, 67]. Here, KRT18 is linked to severe acute respiratory syndrome.