The brain of the patient infected with SARS-CoV exhibited neuronal necrosis, glial hyperplasia, and edema while the viral infection mainly affected neurons [46, 50, 72], which is consistent with studies showing a distinguished neuronal tropism of SARS-CoV in infected K18-hACE2 Tg mice [59, 66]. The gene discussed is KRT18; the disease is viral infectious disease.