Our analysis of only patients with “advanced gastric carcinoma” (AGC; cases with tumor invasion into the proper muscle or deeper; N = 253) revealed that the prognostic factors for AGC were the same as those for the entire cohort, with two exceptions: AGC patients with a low population of CD8+ TILs showed lower rates of overall survival and recurrence-free survival through univariate analysis, and the MSI-high AGC group showed a more favorable clinical outcome (P < 0.05) (Supplemental Fig. 2). Here, CD8A is linked to neoplasm.