In MSI-high gastric carcinomas, the combined subset of tumoral PD-L1(+)/CD8+/low TILs or tumoral PD-L1(+)/immune cell PD-L1(−)/CD8+/low TILs was associated with an adverse outcome for patients (P < 0.05, each) (Fig. 4). This evidence concerns the gene CD274 and gastric carcinoma.