GPT and Cirrhosis: For different classification aims (control vs. CLD, fibrosis vs. cirrhosis, S0–2 vs. S3–4) in an independent validation cohort (cohort 2), the categorical and the continuous NRI and IDI of the RF models all achieved positive values when compared to FIB-4, APRI, and AST/ALT, suggesting an augmentation of classification performances for our biomarker panel and RF models (Additional file 3: Table S5).