GP1BA and bacterial infectious disease: Whilst GPIbα N-linked glycans have previously been thought to be the major target in AMR-mediated clearance due to their tri- or tetra antennary arrangement being preferentially targeted by the AMR [10,11], Wang et al., 2020 [12] uses the neuraminidase-induced mechanism of platelet desialylation to suggest that, during bacterial infections of this type at least, it is GPIbα mono-antennary O-glycans which are the key desialylation targets, that pave the way for enhanced clearance via subsequent desialylation of N-glycans.