Changes in expression or altered function of CaSRs also affects CNS diseases, such as AD and ischemia/hypoxia/stroke, by regulating outward K+ channel fluxes, nitric oxide (NO) and vascular endothelial growth factor A (VEGF-A) overproduction, amyloidogenesis, glial activation, and neuronal death [18,20,21,35,36,37,38]. The gene discussed is VEGFA; the disease is ischemia.