As a consequence of this, tumor cells responded by activating the unfolded protein response machinery (e.g., increased expression of heat shock proteins (HSPs) [40]), inducing mitochondrial biogenesis [41] and upregulating anti-oxidant proteins (e.g., thioredoxins [42], disulfide isomerases [43]) in an attempt to restore redox balance and homeostasis. This evidence concerns the gene TXN and neoplasm.