Recently, it was also reported that SNPs in the 3’ untranslated regions (UTRs) of MTHFR (2572C>A) and thymidylate synthase (1100C>T) are associated with the prevalence of osteoporosis and osteoporotic vertebral compression fracture (OVCF) [12]. The gene discussed is MTHFR; the disease is osteoporosis.