Recently, it was also reported that SNPs in the 3 ́ untranslated regions (UTRs) of MTHFR (2572 C>A) and thymidylate synthase (1100 C>T) are associated with the prevalence of osteoporosis and osteoporotic vertebral compression fractures (OVCFs) [12]. This evidence concerns the gene MTHFR and osteoporosis.