UVRAG and Primary microcephaly: Beclin1 and the ultraviolet irradiation resistance-associated gene (UVRAG) are involved in both autophagy and centrosome stability and linked to ZIKV-mediated microcephaly [42,43] While the recently identified MCPH18, a phosphatidylinositol 3-phosphate-binding protein, functions as a scaffold protein for the autophagic removal of aggregated protein, suggesting a potential link of autophagy in the development of primary microcephaly [44].