IGF1 and diabetic cardiomyopathy: Likewise, hearts of IGF-1 transgenic mice were protected from ischemia and reperfusion [83], and streptozotocin-induced diabetic cardiomyopathy in mice resulted in accumulation of nitrotyrosine (a reactive oxygen product) in vivo and the formation of H2O2 in myocytes in vitro that were rescued in IGF-1 transgenic mice [84].