Regression analysis showed that the change in IBS-SSS could be significantly explained by a linear combination of all the variables considered (i.e., FODMAP content, BMI, COX-2 and the AA/EPA ratio) (F = 6.93; df = 4; p = 0.005; adjusted R2 = 0.71) (Table 8). The gene discussed is PTGS2; the disease is irritable bowel syndrome.