CVD risk factors in shift workers could be due to disturbances of the endocrine system including unfavorable catecholamine, ghrelin (“hunger hormone”), and adipokine excretion, dyslipidemia, metabolic syndrome, insulin resistance and melatonin reduction, and ultimately diabetes [5,6], but also an increased systemic inflammation [7,8,9]—even due to circadian misalignment per se [10]—and changes to the immune system [11]. The gene discussed is GHRL; the disease is metabolic syndrome.