In addition, this data agrees with the study of Huang et al. in which authors demonstrated that BMP-2 can promote EMT in breast cancer via phosphatidylinositol 3-kinases/protein kinase B pathway (PI3K/Akt) [5], a cellular signaling that can be regulated both at extracellular and cytoplasmatic level. The gene discussed is AKT1; the disease is breast carcinoma.