Another study demonstrates that hepatocyte cell-specific GR loss suppresses the development of hyperglycemia in streptozotocin-induced diabetes mellitus, due to the aberrant induction of gluconeogenesis, suggesting that liver-specific GR is critical in the development of hyperglycemia and GR antagonists can control hyperglycemia in mice [267]. The gene discussed is NR3C1; the disease is Hyperglycemia.