CXCL12 and cancer: Moreover, crosstalk regulation between the mTOR pathway and the CXCL12/CXCR4 axis suggests that mTORC1 silencing is sufficient to decrease CXCR4-mediated cancer cell migration, and inhibition of mTORC1 by rapamycin decreases primary tumor growth and CXCR4-mediated lymph node metastasis [141].