The SLNs were surface-modified by using two targeting moieties and, more specifically, glycoprotein antigens, either anti-Contactin2 or anti-Neurofascin, which are two axo-glial-glycoprotein antigens located in the node of Ranvier and are considered to be the main targets of autoimmune reaction in MS. The gene discussed is NFASC; the disease is myeloid sarcoma.