YES1 and non-small cell lung carcinoma: Also, the same authors demonstrated that stable Yes overexpression in human NSCLC cell lines induced proliferation, increased tumor growth and metastasis, but conversely, genetic depletion of Yes using siRNAs or CRISPR/Cas9 in human NSCLC cell lines reduced proliferation, survival, and invasion in vitro and tumor growth and lung metastatic growth.