Specifically, some components of this system (e.g., SST1 and SST2) can contribute to reduce different tumor parameters, including cell proliferation and migration, whereas other components [i.e., the truncated splicing variant of SST5 with four transmembrane domains (SST5TMD4 variant)] promote aggressiveness features of PCa [10,11,12]. This evidence concerns the gene SSTR5 and posterior cortical atrophy.