GPR107 and posterior cortical atrophy: This revealed that GPR107 might exert its tumor-associated functions through modulation of several molecular/signaling pathways, including a decreased activation (basal phosphorylation) of AKT signaling pathway, which has been shown to be a key oncogenic-signaling pathway and cooperate in different tumor pathologies, including PCa, to promote malignancy, drug resistance and CRPC development [49,50].