Specifically, we found that the silencing of GPR107 in 22Rv1 cells significantly decreased the expression levels of the proliferation marker Ki-67 (MKI67), of genes involved in migration process (Matrix Metallopeptidase 9 and Pre-MRNA Processing Factor 40 Homolog A (MMP9 and PRPF40A, respectively)) as well as of key genes associated to PCa aggressiveness such as the oncogenic splicing variants AR-v7, SST5TMD4, Intron 1-retained ghrelin splicing variant (In1-ghrelin) and the Enhancer Of Zeste Homolog 2 (EZH2) (Figure 4a). Here, AR is linked to posterior cortical atrophy.