Altogether, the translational research implications of these findings indicate that GPR107 has a functional role in the pathophysiology of PCa and invites to suggest that pharmacological treatments specifically targeting this receptor, including NST treatment, could become a promising option to treat patients with PCa, specially metastatic PCa, providing a relevant clinical conclusion, which should be soon tested for their use in humans. Here, GPR107 is linked to posterior cortical atrophy.