SST and cancer: In line with this, the somatostatin-SSTRs system represents a useful source of therapeutic targets and tools to treat various endocrine-related tumors, owing to its pleiotropic role encompassing from whole body homeostasis to cancer cell functioning in different tumor types, where this system commonly acts to inhibit multiple processes, such as hormone secretion and cell proliferation, migration and invasion [10,13,32,40,41].