By querying METABRIC data using cBioportal and IPA (Ingenuity Pathway Analysis, Qiagen) network analyses, we found that the majority of genes most frequently altered in human breast cancers were also transcriptionally altered in p53−/− mice and that the direction of change in z-scores (cutoff 1.6) caused by Rlip depletion in these mice resembled those previously reported in Rlip+/− mice (Supplemental Data S11A–C) [42]. The gene discussed is TP53; the disease is breast carcinoma.