The fact that these pathways are regulated by Rlip, as observed in the present experimental studies, taken together with the fact that there are distinct differences in the frequency of mutations, amplifications, and deletions of these and other important genes in breast cancer with respect to Rlip expression, indicates that the interaction of Rlip with these proteins plays a fundamental role in the biological behavior of breast cancer. The gene discussed is RALBP1; the disease is breast carcinoma.