Most remarkably, Rlip is likely an existential requirement of many cancers, as supported by the facts that Rlip-knockout mice are highly resistant to carcinogenesis caused by benzo[a]pyrene [34] and that antisense-mediated depletion of Rlip completely abrogates the development of cancer in p53-null mice, which uniformly die from cancer [42]. This evidence concerns the gene TP53 and cancer.