In addition, obesity-induced kidney damage is caused by hyperglycemic conditions that stimulate the NLR Family Pyrin Domain-Containing 3 (NLRP3) inflammasomes to release IL-1β in podocytes, but the treatment of podocytes with ACDase decreases the NLPR3-induced cytokine release through extracellular vesicles [92]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.