Changes in the Asah1 gene expression in FRBRL patients result in the upregulation of the inflammatory cytokines interleukin 4 (IL-4), IL-6, tumor necrosis factor alpha (TNFα), and macrophage colony stimulating factor (M-CSF) in addition to the angiogenic marker, vascular endothelial growth factor (VEGF) [42,45]. The gene discussed is TNF; the disease is Farber lipogranulomatosis.