ABCB1 and leukemia: For instance, drug resistance in leukemia is mediated by the ACDase activation of the drug transporter molecule ATP-Binding Cassette, Subfamily B, Member 1 (ABCB1), through nuclear factor kappa B (NF-κB) [64], whilst leukemic cancer cell survival is increased by the ACDase-mediated upregulation of the myeloid cell leukemia sequence 1 (MCL-1) [10].