Looking at variants of COX-2, Hedelin et al. (2006) found high intake of salmon-type fish but not n-3 LC-PUFA per se, among subjects who were heterozygous or homozygous for allele (C) of the SNP (rs5275: +6365 T/C) decreased prostate cancer risk by 72% [16]. This evidence concerns the gene PTGS2 and Familial prostate cancer.