For example, a case-control study by Fradet et al. (2009) found that greater intake of n-3 LC-PUFA was significantly associated with lower prostate cancer (PCA) risk in those with the cyclooxygenase-2 (COX-2) single nucleotide polymorphism (SNP) rs4648310 [15]. This evidence concerns the gene PTGS2 and prostate carcinoma.