However, based on the results, HTT potentially increased the Nrf2 levels in the nucleus, simultaneously increasing the HO-1 and NQO1 proteins in a concentration-dependent manner in the cytosol, suggesting that the cytoprotective effects of HTT against FD-induced oxidative damage was carried via the Nrf2/HO-1 signaling pathway. The gene discussed is HMOX1; the disease is Fabry disease.