Three CpGs with a p-value less than or equal to 1.03 × 10−7 (Bonferroni significance threshold) were identified from the 450K array: three CpGs (cg11498607, cg04228935, cg05000748) at the CpG island of RUNX1 showed hypermethylation in tumor tissues compared with normal tissues (Figure 1A). This evidence concerns the gene RUNX1 and neoplasm.