Using MEFs and three NSCLC cell lines (BEAS-2B, H838 and H1299), Liu et al. show that NRF2-null cells have increased ciliogenesis, whereas NRF2 overexpression or stabilization (by pharmacological or genetic inactivation of KEAP1) reduces ciliation. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.