KIT and systemic mastocytosis: Jawhar et al. were the first to show that the presence and number of mutated genes within the SRSF2/ASXL1/RUNX1 (S/A/R) panel was associated with adverse clinical and laboratory features (in terms of MC infiltration in the BM biopsy, serum tryptase levels, KIT D816V allele burden in PB, hemoglobin levels, platelet count, alkaline phosphatase and albumin levels, hepatomegaly with ascites, and weight loss) in a series of 70 patients with SM-AHN [96].