HMGB1 and Sepsis: Our results strongly suggest that the inhibition of HMGB1 action by HRG may contribute to HRG's mortality-reducing protective activity against severe sepsis, and our findings also further explained the mechanism underlying the regulation of neutrophils and endothelium barrier function by HRG under septic conditions in vivo and in vitro (Wake et al., 2016, Gao et al., 2019).