Future comprehensive studies elucidating the regulatory mechanisms for transcription/splicing of Auts2/AUTS2 as well as neurobiological functions of the distinctive AUTS2 isoforms will help us to understand the pathogenic mechanisms underlying the occurrence of a variety of psychiatric disorders in individuals with AUTS2 mutations and could contribute to therapeutic development for AUTS2-related neurological disorders. Here, AUTS2 is linked to nervous system disorder.