CCN2 and recessive dystrophic epidermolysis bullosa: Supporting the development of TGF-β1-mediated fibrosis in untreated RDEB skin and its suppression by DCN-tCRK treatment, strong expression of CTGF/CCN2 was observed in vehicle-injected RDEB skin, and the expression level was markedly diminished after treatment with DCN-tCRK (Figure 6A).