RDEB is caused by mutations in the COL7A1 gene that encodes type VII collagen (C7).9, 10, 11, 12 Clinical manifestations include skin erosions and blistering, mutilating scarring, pseudosyndactyly, and a high risk of developing aggressive and rapidly metastasizing cutaneous squamous cell carcinomas (cSCCs).10 Here, COL7A1 is linked to recessive dystrophic epidermolysis bullosa.