NR3C1 and congenital adrenal hyperplasia: We previously found altered methylation status in genes relevant for brain development and function in DEX-treated individuals not having CAH, including brain-derived neurotrophic factor (BDNF), the GC receptor (GR) NR3C1, the mineralocorticoid receptor NR3C2, and the GR co-chaperone FKBP5 gene (15).