IFN-γ is a well-known Th1 cell-produced cytokine, TNF-α is associated with a pro-inflammatory state and may also be secreted by Th1 cells [80], and IL-17A is a marker of CD4+ Th17 lymphocytes, which are associated with autoimmunity, inflammation, and chronic pain [81]. The gene discussed is IFNG; the disease is Autoimmunity.