After matching with known information, we determined that CDC42 [23, 24], CDK11A [25–27], SAC3D1 [28–30], CCNK [31], and INCENP [32–34] were involved in mitosis and apoptosis progression and might be potential downstream targets by which RBM17 can regulate cell proliferation in the development and progression of HCC. The gene discussed is INCENP; the disease is hepatocellular carcinoma.