PIAS1 and breast cancer: The products of YWHAQ (14-3-3ε) regulate TP53 through protein-protein interactions and post-translational modifications [40], and the germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ, might affect prognosis and treatment outcome in breast cancer patients [41].