In early 2000s, insights based on microscopic observations of the fallopian tubes and ovaries prophylactically removed from high-risk women carrying BRCA1/2 mutations had led to a hypothesis [70, 71]: that a non-invasive microscopic tumor lesion formed in the fallopian tube epithelium, termed serous tubal intraepithelial carcinoma (STIC), may be a cell of origin of human HGSC [21, 72]. The gene discussed is BRCA1; the disease is neoplasm.