However, genetic mutations of the p53 gene alone do not appear to be sufficient to cause HGSC, as evidenced by the lack of ovarian cancer in patients with Li-Fraumeni syndrome harboring germline p53 mutations and the scant development of HGSC in mouse models with p53 mutations [7, 24, 26, 27, 29]. Here, TP53 is linked to Li-Fraumeni syndrome.