CASP3 and Alzheimer disease: In our study, treatment with LM‐031 upregulated antioxidant NRF2 pathway and reduced proapoptotic BAX and CASP3 expression in pro‐aggregated TauRD‐DsRed‐expressing SH‐SY5Y cells, supporting the role of LM‐031 in treating AD by preventing oxidative stress and blocking apoptosis pathway.