Although Tau pathology is thought to be downstream (and occur after) of amyloid pathology in 3 × Tg‐AD mice, the decrease of pathological Aβ aggregation may be explained by the anti‐aggregation, antioxidant, and neuroprotective effects of LM‐031 against Aβ misfolding and toxicity (Lee et al., 2018). Here, MAPT is linked to Alzheimer disease.