MAPT and Alzheimer disease: In vivo, the observed beneficial effects of LM‐031 on learning and memory improvement in hyperglycemic 3 × Tg‐AD mice (Figure 4) could be mediated by upregulating NRF2 and pCREB and reducing Aβ and Tau levels in hippocampus and cortex of the hyperglycemic 3 × Tg‐AD mice (Figures 5, 6).