In our study, LM‐031 demonstrated its potential of enhancing CREB‐dependent gene transcription including BDNF, ERK, AKT, BCL2, and GADD45B, all of which are important to neuronal survival, in pro‐aggregated TauRD‐DsRed‐expressing SH‐SY5Y cells (Figure 2), further highlighting its possible role as a novel compound targeting multiple pathways in AD treatment. Here, GADD45B is linked to Alzheimer disease.