CREB downregulation has been implicated in the pathology of AD (Bartolotti, Bennett, & Lazarov, 2016; Pugazhenthi, Wang, Pham, Sze, & Eckman, 2011; Yamamoto‐Sasaki, Ozawa, Saito, Rosler, & Riederer, 1999). This evidence concerns the gene CREB1 and Alzheimer disease.