The interaction between PATZ1 and the tumour suppressor p53 (Valentino, Palmieri, Vitiello, Pierantoni et al., 2013 ▸; Valentino, Palmieri, Vitiello, Simeone et al., 2013 ▸; Chiappetta et al., 2015 ▸; Keskin et al., 2015 ▸) mediated by a motif in the zinc-finger DNA-binding domain rather than the BTB domain also links this protein to cancer. This evidence concerns the gene PATZ1 and cancer.