In addition, overexpression of miR-137 enhances viability and suppresses apoptosis of neuronal cells, decreases cleaved caspase 3 levels and increases Bcl-2 protein levels in a cell model of Alzheimer's disease, highlighting its neuronal protective effects [23], which was in accordance with our findings. This evidence concerns the gene CASP3 and early-onset autosomal dominant Alzheimer disease.