RhoA binds to multiple target proteins, including epidermal growth factor receptor (EGFR) and Rho-associated coiled-coil-forming protein kinase (ROCK), and regulates cytoskeletal dynamics and gene transcription [8], thereby regulating the adhesion, movement, and contraction of HSCs and participating in the development of liver fibrosis [9]. The gene discussed is RHOA; the disease is Hepatic fibrosis.