In NOX4 knockout liver fibrotic mice, the levels of serum indicators that reflect the expression of the ROS indicator MDA and the expression of liver fibrosis-related factors also declined to a certain degree, indicating that the NOX4/ROS signalling pathway plays a role in improving liver fibrosis and that intervention in this pathway can reverse the progression of liver fibrosis. This evidence concerns the gene NOX4 and Hepatic fibrosis.