SGCG and Immunodeficiency: These secondary immunodeficiencies thus represent the correlate of the findings in PIDs either interfering with induction of type I IFN responses as seen in POL III and TLR3 deficiencies, or interfering with responses to type I and type II IFN as documented in STAT1 LOF and TYK2 deficiencies and thus underscore the fundamental importance of IFNs in protective immunity against VZV.