These secondary immunodeficiencies thus represent the correlate of the findings in PIDs either interfering with induction of type I IFN responses as seen in POL III and TLR3 deficiencies, or interfering with responses to type I and type II IFN as documented in STAT1 LOF and TYK2 deficiencies and thus underscore the fundamental importance of IFNs in protective immunity against VZV. This evidence concerns the gene SGCG and immunodeficiency disease.